Not automatically.
Waiting may be sensible if you need more savings, a better offer or time to explore alternatives. But if your job has become persistently unhealthy, waiting without addressing the situation may only prolong the problem.
First assess what is happening at work and what you have already tried. Consider whether an internal move, a change in responsibilities or a planned job search could help.
A traditional Vedic interpretation of the Antardasha can be one part of your reflection. It cannot guarantee whether resignation will succeed.
The useful question is not simply whether the current period is favourable. It is whether you have a reasonable plan for your next step.
https://www.wisdom.vedaspark.com/faqs/should-i-quit-my-job-during-a-difficult-mahadasha